D2HGDH Rabbit Polyclonal Antibody (CAB16213)
- SKU:
- CAB16213
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | D2HGDH Rabbit Polyclonal Antibody |
SKU: | CAB16213 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 322-521 of human D2HGDH (NP_689996.4). |
Sequence: | GRHL HLAS PVQE SPFY VLIE TSGS NAGH DAEK LGHF LEHA LGSG LVTD GTMA TDQR KVKM LWAL RERI TEAL SRDG YVYK YDLS LPVE RLYD IVTD LRAR LGPH AKHV VGYG HLGD GNLH LNVT AEAF SPSL LAAL EPHV YEWT AGQQ GSVS AEHG VGFR KRDV LGYS KPPG ALQL MQQL KALL DPKG ILNP YKTL PSQA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | D2HGD; D2HGDH |
Positive Sample: | Mouse liver,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | mitochondrial matrix, mitochondrion |
Calculated MW: | 56kDa |
Observed MW: | 56kDa |
This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.
Purification Method: | Affinity purification |
Gene ID: | 728294 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |