The Cytokeratin 20 (KRT20) Polyclonal Antibody is a valuable tool for researchers studying cytokeratin 20, a protein found in epithelial cells and widely used as a specific marker for colorectal and urothelial carcinomas. This antibody, produced in rabbits, displays high reactivity with human samples and is validated for use in various applications, including immunohistochemistry and Western blotting.Cytokeratin 20 is a member of the cytokeratin family, which plays a critical role in maintaining the structural integrity of epithelial cells. Abnormal expression of cytokeratin 20 has been linked to various cancers, making it an important biomarker for diagnostic and prognostic purposes.
The KRT20 Polyclonal Antibody binds specifically to cytokeratin 20, allowing for precise detection and analysis in tissue samples, making it an essential tool for cancer research and diagnostics.Researchers studying colorectal and urothelial carcinomas, as well as other epithelial cell-related diseases, can benefit from the high reactivity and specificity of the KRT20 Polyclonal Antibody. By accurately detecting and analyzing cytokeratin 20 expression, this antibody aids in further understanding the role of this protein in disease development and progression, ultimately leading to the development of improved diagnostic and therapeutic strategies.
Product Name:
Cytokeratin 20 (KRT20) Polyclonal Antibody
SKU:
CAB21552
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 245-424 of human Cytokeratin 20 (KRT20) (NP_061883.1).
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21.
Purification Method:
Affinity purification
Gene ID:
54474
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cytokeratin 20 (KRT20) Rabbit pAb (CAB21552).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
