CYP3A5 Rabbit Polyclonal Antibody (CAB7663)
- SKU:
- CAB7663
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | CYP3A5 Rabbit Polyclonal Antibody |
SKU: | CAB7663 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 233-502 of human CYP3A5 (NP_000768.1). |
Sequence: | FEAL NVSL FPKD TINF LSKS VNRM KKSR LNDK QKHR LDFL QLMI DSQN SKET ESHK ALSD LELA AQSI IFIF AGYE TTSS VLSF TLYE LATH PDVQ QKLQ KEID AVLP NKAP PTYD AVVQ MEYL DMVV NETL RLFP VAIR LERT CKKD VEIN GVFI PKGS MVVI PTYA LHHD PKYW TEPE EFRP ERFS KKKD SIDP YIYT PFGT GPRN CIGM RFAL MNMK LALI RVLQ NFSF KPCK ETQI PLKL DTQG LLQP EKPI VLKV DSRD GTLS GE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CP35; PCN3; CYPIIIA5; P450PCN3; CYP3A5 |
Positive Sample: | Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein. |
Calculated MW: | 57kDa |
Observed MW: | 57kDa |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 1577 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |