The Cytochrome P450 3A5 Polyclonal Antibody (CAB7663) is a valuable tool for researchers studying the function of the cytochrome P450 3A5 enzyme. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the cytochrome P450 3A5 protein, researchers can easily detect and analyze its expression in various cell types.Cytochrome P450 3A5 is a key enzyme involved in the metabolism of drugs, toxins, and endogenous compounds in the liver and other tissues. Variations in the expression and activity of this enzyme can impact drug metabolism and response, making it an important target for pharmacogenomic research.
The Cytochrome P450 3A5 Polyclonal Antibody enables researchers to investigate the role of this enzyme in drug metabolism, drug interactions, and personalized medicine approaches.Overall, the Cytochrome P450 3A5 Polyclonal Antibody is a valuable tool for researchers interested in understanding the function and regulation of cytochrome P450 3A5 in health and disease. Its high specificity and reactivity make it a reliable choice for studies in pharmacology, toxicology, and personalized medicine.
Product Name:
CYP3A5 Rabbit Polyclonal Antibody
SKU:
CAB7663
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 233-502 of human CYP3A5 (NP_000768.1).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1577
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat thymus, using CYP3A5 antibody (CAB7663) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
