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CYP2E1 Rabbit Polyclonal Antibody (CAB2160)

SKU:
CAB2160
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
  • Metabolism Antibodies 2 Anti-CYP2E1 Antibody CAB2160
  • Metabolism Antibodies 2 Anti-CYP2E1 Antibody CAB2160
  • Metabolism Antibodies 2 Anti-CYP2E1 Antibody CAB2160
  • Metabolism Antibodies 2 Anti-CYP2E1 Antibody CAB2160
€139 - €419
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Description

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CYP2E1 Rabbit Polyclonal Antibody (CAB2160)

The Cytochrome P450 2E1 Polyclonal Antibody (CAB2160) is a research tool designed for studying Cytochrome P450 2E1, an enzyme involved in drug metabolism and detoxification processes in the liver. Raised in rabbits, this antibody offers high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the Cytochrome P450 2E1 protein, researchers can easily detect and analyze its expression in various cell types, making it ideal for studies in pharmacology and toxicology.Cytochrome P450 2E1 is known for its role in metabolizing a wide range of chemical compounds, including environmental toxins and commonly used medications.

Understanding the function and activity of this enzyme is crucial for predicting drug interactions, determining drug efficacy, and assessing toxicological risks. The Cytochrome P450 2E1 Polyclonal Antibody provides a reliable tool for researchers investigating the complex mechanisms of drug metabolism and liver function, with potential applications in drug development and personalized medicine.

Product Name:CYP2E1 Rabbit Polyclonal Antibody
SKU:CAB2160
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 234-493 of human CYP2E1 (NP_000764.1).
Sequence:KVIK NVAE VKEY VSER VKEH HQSL DPNC PRDL TDCL LVEM EKEK HSAE RLYT MDGI TVTV ADLF FAGT ETTS TTLR YGLL ILMK YPEI EEKL HEEI DRVI GPSR IPAI KDRQ EMPY MDAV VHEI QRFI TLVP SNLP HEAT RDTI FRGY LIPK GTVV VPTL DSVL YDNQ EFPD PEKF KPEH FLNE NGKF KYSD YFKP FSTG KRVC AGEG LARM ELFL LLCA ILQH FNLK PLVD PKDI DLSP IHIG FGCI PPRY KLCV IPRS
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:CPE1; CYP2E; P450-J; P450C2E; CYP2E1
Positive Sample:Rat liver
Conjugate:Unconjugated
Cellular Localization:Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein.
Calculated MW:57kDa
Observed MW:55kDa

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Purification Method:Affinity purification
Gene ID:1571
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Rat liver, using CYP2E1 Rabbit pAb (CAB2160) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 0.5s.

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