The Cytochrome P450 2D6 Polyclonal Antibody (CAB1299) is a valuable tool for researchers studying the Cytochrome P450 2D6 enzyme, which plays a critical role in drug metabolism and is involved in the metabolism of a wide range of pharmaceuticals. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.Cytochrome P450 2D6 is known for its importance in the metabolism of various drugs, including antidepressants, antipsychotics, and anti-cancer medications. Understanding the activity and regulation of this enzyme is crucial for predicting individual responses to medications and optimizing drug therapies for personalized medicine approaches.
This antibody binds specifically to Cytochrome P450 2D6, allowing for accurate detection and analysis of this enzyme in various cell types. Its reliability and specificity make it an essential tool for research in pharmacology, toxicology, and personalized medicine, with potential applications in drug development and optimizing treatment strategies for patients.
Product Name:
CYP2D6 Rabbit Polyclonal Antibody
SKU:
CAB1299
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-230 of human CYP2D6 (NP_000097.3).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1565
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CYP2D6 Rabbit pAb (CAB1299) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
