The Cytochrome P450 2B6 Polyclonal Antibody (CAB1463) is a crucial tool for researchers studying Cytochrome P450 2B6, an important enzyme involved in drug metabolism and detoxification. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the Cytochrome P450 2B6 protein, this antibody allows for precise detection and analysis in various cell types, making it an excellent choice for investigations in pharmacology and toxicology.
Cytochrome P450 2B6 is known for its role in metabolizing a wide range of drugs, including antiretrovirals, anticancer agents, and antidepressants. Understanding the expression and activity of this enzyme is essential for predicting drug efficacy, drug interactions, and potential toxicity in patients. The Cytochrome P450 2B6 Polyclonal Antibody provides researchers with a reliable tool to explore the function and regulation of this enzyme, ultimately contributing to the development of safer and more effective medications.
Product Name:
CYP2B6 Rabbit Polyclonal Antibody
SKU:
CAB1463
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 160-340 of human CYP2B6 (NP_000758.1).
Sequence:
SKGA LMDP TFLF QSIT ANII CSIV FGKR FHYQ DQEF LKML NLFY QTFS LISS VFGQ LFEL FSGF LKYF PGAH RQVY KNLQ EINA YIGH SVEK HRET LDPS APKD LIDT YLLH MEKE KSNA HSEF SHQN LNLN TLSL FFAG TETT STTL RYGF LLML KYPH VAER VYRE IEQV IGPH RPPE L
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
Purification Method:
Affinity purification
Gene ID:
1555
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CYP2B6 Rabbit pAb (CAB1463) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
