CYP2B6 Rabbit Polyclonal Antibody (CAB1463)
- SKU:
- CAB1463
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | CYP2B6 Rabbit Polyclonal Antibody |
SKU: | CAB1463 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-340 of human CYP2B6 (NP_000758.1). |
Sequence: | SKGA LMDP TFLF QSIT ANII CSIV FGKR FHYQ DQEF LKML NLFY QTFS LISS VFGQ LFEL FSGF LKYF PGAH RQVY KNLQ EINA YIGH SVEK HRET LDPS APKD LIDT YLLH MEKE KSNA HSEF SHQN LNLN TLSL FFAG TETT STTL RYGF LLML KYPH VAER VYRE IEQV IGPH RPPE L |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:100 |
Synonyms: | CPB6; EFVM; IIB1; P450; CYP2B; CYP2B7; CYP2B7P; CYPIIB6; CYP2B6 |
Positive Sample: | NCI-H460,HT-29,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein. |
Calculated MW: | 56kDa |
Observed MW: | 66kDa |
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
Purification Method: | Affinity purification |
Gene ID: | 1555 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |