CYP1B1 Rabbit Polyclonal Antibody (CAB1377)
- SKU:
- CAB1377
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | CYP1B1 Rabbit Polyclonal Antibody |
SKU: | CAB1377 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human CYP1B1 (NP_000095.2). |
Sequence: | MGTS LSPN DPWP LNPL SIQQ TTLL LLLS VLAT VHVG QRLL RQRR RQLR SAPP GPFA WPLI GNAA AVGQ AAHL SFAR LARR YGDV FQIR LGSC PIVV LNGE RAIH QALV QQGS AFAD RPAF ASFR VVSG GRSM AFGH YSEH WKVQ RRAA HSMM RNFF TRQP RSRQ VLEG HVLS EARE LVAL LVRG SADG AFLD PRPL TVVA VANV MSAV CFGC RYSH DDPE FREL LSHN EEFG RTVG AGSL VDVM PWLQ YFPN PVRT VFRE |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | CP1B; ASGD6; GLC3A; CYPIB1; P4501B1; CYP1B1 |
Positive Sample: | A-549,MCF7,HL-60,HT-29,Mouse kidney,Mouse heart,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Microsome membrane, Mitochondrion, Peripheral membrane protein. |
Calculated MW: | 61kDa |
Observed MW: | 60kDa |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.
Purification Method: | Affinity purification |
Gene ID: | 1545 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |