The Cytidine Deaminase Polyclonal Antibody (CAB2006) is a valuable tool for researchers studying cytidine deaminase, an enzyme involved in the metabolism of nucleic acids. This antibody, produced in rabbits, specifically targets cytidine deaminase and is highly reactive with human samples. It has been validated for use in Western blot applications, allowing for the detection and analysis of cytidine deaminase in various cell types.Cytidine deaminase plays a critical role in the conversion of cytidine to uridine, a process that is crucial for DNA and RNA synthesis. Dysregulation of cytidine deaminase has been linked to various diseases, including cancer and autoimmune disorders.
By studying the activity and expression of cytidine deaminase, researchers can gain insight into the underlying mechanisms of these diseases and potentially develop targeted therapies.This antibody is a valuable tool for researchers in the fields of biochemistry, molecular biology, and pharmacology, who are interested in investigating the role of cytidine deaminase in health and disease. Its high reactivity and specificity make it an ideal choice for studies aimed at unraveling the complex functions of this important enzyme.
Product Name:
CDA Rabbit Polyclonal Antibody
SKU:
CAB2006
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-146 of human CDA (NP_001776.1).
This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.
Purification Method:
Affinity purification
Gene ID:
978
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Mouse kidney, using CDA antibody (CAB2006) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
