The Cyth4 Polyclonal Antibody (CAB14875) is a valuable tool for researchers studying Cyth4, a protein involved in cell signaling and cytoskeletal dynamics. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the Cyth4 protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for investigations in cell biology and signal transduction research.Cyth4, also known as Cytohesin 4, plays a crucial role in regulating cellular processes such as cell migration, adhesion, and vesicular trafficking.
Its involvement in signaling pathways related to cell growth and differentiation make it a promising target for studying diseases like cancer, neurodegenerative disorders, and cardiovascular diseases. Understanding the function of Cyth4 is essential for developing therapeutic strategies that target aberrant cell signaling pathways in these conditions.Overall, the Cyth4 Polyclonal Antibody (CAB14875) is a reliable tool for researchers seeking to delve deeper into the mechanisms underlying cell signaling and cytoskeletal dynamics, with the potential to contribute valuable insights into various disease processes.
Product Name:
CYTH4 Rabbit Polyclonal Antibody
SKU:
CAB14875
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human CYTH4 (NP_037517.1).
This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family function as GEPs for ADP-ribosylation factors (ARFs), which are guanine nucleotide-binding proteins involved in vesicular trafficking pathways. This protein exhibits GEP activity in vitro with ARF1 and ARF5, but is inactive with ARF6. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
27128
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CYTH4 Rabbit pAb (CAB14875) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
