The CYTH3 Polyclonal Antibody (PACO08729) is a valuable tool for researchers studying CYTH3, a protein involved in cell signaling and membrane trafficking. This antibody, produced in rabbits, shows high specificity for human samples and is validated for use in Western blot applications. By binding to CYTH3, the antibody facilitates the detection and analysis of this crucial protein in various cell types, making it an essential component for investigations in cell biology and signal transduction pathways.
CYTH3, also known as Cytohesin 3, plays a key role in the regulation of cellular processes such as vesicle trafficking and receptor signaling. Its involvement in intracellular signaling cascades makes it a promising target for research in areas like cancer biology, neurodegenerative diseases, and metabolic disorders. By understanding the function of CYTH3, researchers can uncover potential therapeutic strategies for targeting these diseases and developing novel treatment approaches.
cytohesin 3: Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Receptor, misc.; GEFs; GEFs, ARF; Lipid-binding; Nuclear receptor co-regulatorChromosomal Location of Human Ortholog: 7p22.1Cellular Component: ruffle; extrinsic to internal side of plasma membrane; plasma membrane; trans-Golgi network; cytosolMolecular Function: phosphatidylinositol-3,4,5-triphosphate binding; ARF guanyl-nucleotide exchange factor activityBiological Process: regulation of cell adhesion; vesicle-mediated transport; positive regulation of cell adhesion; regulation of ARF protein signal transduction; positive regulation of GTPase activity; Golgi vesicle transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008]
ARF nucleotide-binding site opener 3; Protein ARNO3; General receptor of phosphoinositides 1; Grp1; PH, SEC7 and coiled-coil domain-containing protein 3
