The CYTH3 Polyclonal Antibody (PACO00889) is specifically designed for research involving CYTH3, a protein involved in cell signaling pathways and membrane trafficking. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot and immunohistochemistry applications. By binding to CYTH3, this antibody allows for the detection and analysis of this protein in various cell types, making it an ideal tool for studies in cell biology and signal transduction research.CYTH3, also known as Arf-GAP with coiled-coil, ankyrin repeat and PH domains 2 (ACAP2), is involved in regulating the GTPase activity of Arf proteins, which play crucial roles in vesicle trafficking and membrane dynamics.
Understanding the function of CYTH3 can provide insights into cellular processes such as endocytosis, exocytosis, and cytoskeletal organization. Additionally, dysregulation of CYTH3 has been implicated in various diseases, making it a potential target for therapeutic intervention.Overall, the CYTH3 Polyclonal Antibody is a valuable tool for researchers interested in studying the role of CYTH3 in cellular signaling and membrane trafficking pathways, with potential implications for drug discovery and disease treatment strategies.
Antibody Name:
CYTH3 Antibody
Antibody SKU:
PACO00889
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat, Monkey
Immunogen:
synthesized peptide derived from the C-terminal region of human GRP1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CYTH3; ARNO3; GRP1; PSCD3; Cytohesin-3; ARF nucleotide-binding site opener 3; Protein ARNO3; General receptor of phosphoinositides 1; Grp1; PH; SEC7 and coiled-coil domain-containing protein 3
UniProt Protein Function:
cytohesin 3: Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Receptor, misc.; GEFs; GEFs, ARF; Lipid-binding; Nuclear receptor co-regulatorChromosomal Location of Human Ortholog: 7p22.1Cellular Component: ruffle; extrinsic to internal side of plasma membrane; plasma membrane; trans-Golgi network; cytosolMolecular Function: phosphatidylinositol-3,4,5-triphosphate binding; ARF guanyl-nucleotide exchange factor activityBiological Process: regulation of cell adhesion; vesicle-mediated transport; positive regulation of cell adhesion; regulation of ARF protein signal transduction; positive regulation of GTPase activity; Golgi vesicle transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008]
ARF nucleotide-binding site opener 3; Protein ARNO3; General receptor of phosphoinositides 1; Grp1; PH, SEC7 and coiled-coil domain-containing protein 3
