The Cystatin C Rabbit Monoclonal Antibody (CAB8933) is a high-quality antibody designed for research involving Cystatin C, a protein known for its role in kidney function and as a biomarker for various diseases. This antibody has been specifically raised in rabbits and is highly reactive with human samples, making it ideal for use in a variety of research applications.Cystatin C is a cysteine proteinase inhibitor that is primarily produced by nucleated cells and is involved in regulating enzyme activity. It has been shown to be a reliable marker for kidney function, with levels in the blood correlating with glomerular filtration rate. Additionally, Cystatin C has been implicated in various disease processes, including cardiovascular disease, diabetes, and neurodegenerative disorders.
The Cystatin C Rabbit Monoclonal Antibody (CAB8933) can be used for Western blot analysis, immunohistochemistry, and other research techniques to detect and analyze Cystatin C in different cell types and tissue samples. Its high specificity and sensitivity make it a valuable tool for studies in nephrology, cardiovascular research, and other fields where Cystatin C is of interest. By understanding the role of Cystatin C in various diseases and biological processes, researchers can develop new insights and potential therapeutic strategies.
Product Name:
Cystatin C Rabbit Monoclonal Antibody
SKU:
CAB8933
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-146 of human Cystatin C (P01034).
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein.
Purification Method:
Affinity purification
Gene ID:
1471
Clone Number:
ARC1357
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Cystatin C Rabbit mAb (CAB8933) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
