The Cystatin C Polyclonal Antibody (CAB1561) is a valuable tool for researchers studying cystatin C, a protein that plays a key role in regulating the activity of cysteine proteases in various physiological processes. This antibody, generated in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications.Cystatin C is a cysteine protease inhibitor that is involved in the regulation of proteolytic activity, making it an important target for investigation in studies related to various diseases and conditions, including cancer, cardiovascular diseases, and neurodegenerative disorders.
By targeting cystatin C, researchers can gain insights into its functions and potential implications in disease pathogenesis.Overall, the Cystatin C Polyclonal Antibody is a reliable tool for researchers looking to explore the roles and functions of cystatin C in different biological processes, offering valuable insights for potential therapeutic interventions and furthering our understanding of disease mechanisms.
Product Name:
Cystatin C Rabbit Polyclonal Antibody
SKU:
CAB1561
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-146 of human Cystatin C (NP_000090.1).
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein.
Purification Method:
Affinity purification
Gene ID:
1471
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Hep G2, using Cystatin C Rabbit pAb (CAB1561) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
