The Cystatin A Polyclonal Antibody (CAB5686) is a valuable tool for researchers studying the cystatin A protein, which is involved in various physiological and pathological processes, including immune regulation and anti-inflammatory activities. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications.Cystatin A, a member of the cystatin superfamily, plays a crucial role in modulating protease activity and is implicated in regulating immune responses and inflammation. Its dysregulation has been linked to various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.
By targeting cystatin A, researchers can gain valuable insights into the underlying mechanisms of these conditions and potentially develop novel therapeutic strategies.The Cystatin A Polyclonal Antibody enables precise detection and analysis of cystatin A protein expression in different cell types, making it a versatile tool for studies in immunology, cancer biology, and other related fields. By understanding the functions of cystatin A, researchers can uncover new therapeutic targets and diagnostic markers for diseases associated with abnormal immune responses and protease activity.
Product Name:
CSTA Rabbit Polyclonal Antibody
SKU:
CAB5686
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-98 of human CSTA (NP_005204.1).
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer.
Purification Method:
Affinity purification
Gene ID:
1475
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of THP-1 cells, using CSTA antibody (CAB5686) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
