The CysLT1 Polyclonal Antibody (CAB1815) is a valuable tool for researchers studying the Cysteinyl leukotriene receptor 1 (CysLT1), a key player in inflammatory and allergic responses. The antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications. By binding to the CysLT1 protein, this antibody enables the detection and analysis of CysLT1 in various cell types, making it an essential reagent for studies in immunology, allergy, and inflammation research.
CysLT1 is a crucial mediator in the pathogenesis of asthma, allergic rhinitis, and other inflammatory conditions, making it a promising target for the development of therapeutic strategies. By understanding the role of CysLT1 in mediating inflammatory responses, researchers can work towards developing more effective treatments for these conditions. The CysLT1 Polyclonal Antibody is a valuable tool for investigating the function of CysLT1 and its potential as a therapeutic target in various diseases.
Product Name:
CYSLTR1 Rabbit Polyclonal Antibody
SKU:
CAB1815
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CYSLTR1 (NP_006630.1).
This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10800
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CYSLTR1 Rabbit pAb (CAB1815) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
