CYP4A11/CYP4A22 Antibody (PACO22779)
- SKU:
- PACO22779
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CYP4A11/CYP4A22 Antibody (PACO22779)
The CYP4A11/CYP4A22 Polyclonal Antibody (PACO22779) is a valuable tool for researchers studying CYP4A11 and CYP4A22, two important enzymes involved in fatty acid metabolism and the synthesis of eicosanoids. The antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically targeting the CYP4A11 and CYP4A22 proteins, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for studies in pharmacology, lipid metabolism, and cardiovascular research.
CYP4A11 and CYP4A22 are key enzymes in the cytochrome P450 family, playing crucial roles in the metabolism of fatty acids and the regulation of eicosanoid synthesis. Dysregulation of these enzymes has been implicated in various diseases, including hypertension, diabetes, and cardiovascular disorders. Research into the function and expression of CYP4A11 and CYP4A22 is vital for uncovering their roles in health and disease, as well as for developing new therapeutic strategies targeting these enzymes.
| Antibody Name: | CYP4A11/CYP4A22 Antibody (PACO22779) |
| Antibody SKU: | PACO22779 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human CYTOCHROME P450 4A11/22. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from COLO205, HuvEc and HeLa cells, using CYTOCHROME P450 4A11/22 antibody. |
| Background: | Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). |
| Synonyms: | CYP4A11 protein; |
| UniProt Protein Function: | CYP4A11: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Oxidoreductase; Lipid Metabolism - fatty acid; Lipid Metabolism - arachidonic acid; EC 1.14.15.3; Cofactor and Vitamin Metabolism - retinol Chromosomal Location of Human Ortholog: 1p33 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; apical plasma membrane; cytoplasm Molecular Function:leukotriene-B4 20-monooxygenase activity; iron ion binding; heme binding; arachidonic acid epoxygenase activity; alkane 1-monooxygenase activity Biological Process: xenobiotic metabolic process; positive regulation of icosanoid secretion; renal water homeostasis; arachidonic acid metabolic process; leukotriene metabolic process; sodium ion homeostasis; epoxygenase P450 pathway; cellular lipid metabolic process; long-chain fatty acid metabolic process; fatty acid metabolic process; pressure natriuresis |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q02928 |
| NCBI GenInfo Identifier: | 2493371 |
| NCBI Gene ID: | 1579 |
| NCBI Accession: | Q02928.1 |
| UniProt Secondary Accession: | Q02928,Q06766, Q16865, Q16866, Q5VSP8, Q86SU6, Q8IWY5 |
| UniProt Related Accession: | Q02928 |
| Molecular Weight: | 519 |
| NCBI Full Name: | Cytochrome P450 4A11 |
| NCBI Synonym Full Names: | cytochrome P450, family 4, subfamily A, polypeptide 11 |
| NCBI Official Symbol: | CYP4A11Â Â |
| NCBI Official Synonym Symbols: | CP4Y; CYP4A2; CYP4AIIÂ Â |
| NCBI Protein Information: | cytochrome P450 4A11; CYPIVA11; P450HL-omega; 20-HETE synthase; alkane-1 monooxygenase; cytochrome P450HL-omega; cytochrome P-450HK-omega; fatty acid omega-hydroxylase; lauric acid omega-hydroxylase; 20-hydroxyeicosatetraenoic acid synthase; cytochrome P450, subfamily IVA, polypeptide 11 |
| UniProt Protein Name: | Cytochrome P450 4A11 |
| UniProt Synonym Protein Names: | 20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; CYP4AII; CYPIVA11; Cytochrome P-450HK-omega; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase (EC:1.14.15.3) |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP4A11Â Â |
| UniProt Entry Name: | CP4AB_HUMAN |
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