CYP4A11/CYP4A22 Antibody (PACO00670)
- SKU:
- PACO00670
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CYP4A11/CYP4A22 Antibody (PACO00670)
The CYP4A11/CYP4A22 Polyclonal Antibody (PACO00670) is a valuable tool for researchers studying cytochrome P450 enzymes involved in fatty acid metabolism and drug metabolism. This antibody, raised in rabbits, has high sensitivity and specificity for detecting CYP4A11 and CYP4A22 proteins in human samples, making it ideal for use in Western blotting experiments.Cytochrome P450 enzymes, such as CYP4A11 and CYP4A22, play essential roles in the metabolism of fatty acids and drugs in the liver. Dysregulation of these enzymes has been implicated in various diseases, including metabolic disorders, cardiovascular diseases, and drug toxicity.
The CYP4A11/CYP4A22 Polyclonal Antibody allows for the precise detection and quantification of these enzymes in various cell types, offering insights into their roles in health and disease.By using the CYP4A11/CYP4A22 Polyclonal Antibody in research, scientists can further understand the functions of these cytochrome P450 enzymes and their contribution to physiological processes and pathologies. This antibody serves as a valuable tool for investigating the molecular mechanisms underlying fatty acid metabolism and drug metabolism, paving the way for the development of novel therapeutic approaches targeting these enzymes.
| Antibody Name: | CYP4A11/CYP4A22 Antibody |
| Antibody SKU: | PACO00670 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | synthesized peptide derived from the Internal region of human CYP4A11/22. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | CYP4A11; CYP4A2; Cytochrome P450 4A11; 20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; CYP4AII; CYPIVA11; Cytochrome P-450HK-omega; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase; CYP4A22; C |
| UniProt Protein Function: | CYP4A11: Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Oxidoreductase; Lipid Metabolism - fatty acid; Lipid Metabolism - arachidonic acid; EC 1.14.15.3; Cofactor and Vitamin Metabolism - retinol Chromosomal Location of Human Ortholog: 1p33 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; apical plasma membrane; cytoplasm Molecular Function:leukotriene-B4 20-monooxygenase activity; iron ion binding; heme binding; arachidonic acid epoxygenase activity; alkane 1-monooxygenase activity Biological Process: xenobiotic metabolic process; positive regulation of icosanoid secretion; renal water homeostasis; arachidonic acid metabolic process; leukotriene metabolic process; sodium ion homeostasis; epoxygenase P450 pathway; cellular lipid metabolic process; long-chain fatty acid metabolic process; fatty acid metabolic process; pressure natriuresis |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q02928 |
| NCBI GenInfo Identifier: | 2493371 |
| NCBI Gene ID: | 1579 |
| NCBI Accession: | Q02928.1 |
| UniProt Secondary Accession: | Q02928,Q06766, Q16865, Q16866, Q5VSP8, Q86SU6, Q8IWY5 |
| UniProt Related Accession: | Q02928 |
| Molecular Weight: | 519 |
| NCBI Full Name: | Cytochrome P450 4A11 |
| NCBI Synonym Full Names: | cytochrome P450, family 4, subfamily A, polypeptide 11 |
| NCBI Official Symbol: | CYP4A11Â Â |
| NCBI Official Synonym Symbols: | CP4Y; CYP4A2; CYP4AIIÂ Â |
| NCBI Protein Information: | cytochrome P450 4A11; CYPIVA11; P450HL-omega; 20-HETE synthase; alkane-1 monooxygenase; cytochrome P450HL-omega; cytochrome P-450HK-omega; fatty acid omega-hydroxylase; lauric acid omega-hydroxylase; 20-hydroxyeicosatetraenoic acid synthase; cytochrome P450, subfamily IVA, polypeptide 11 |
| UniProt Protein Name: | Cytochrome P450 4A11 |
| UniProt Synonym Protein Names: | 20-hydroxyeicosatetraenoic acid synthase; 20-HETE synthase; CYP4AII; CYPIVA11; Cytochrome P-450HK-omega; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase (EC:1.14.15.3) |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP4A11Â Â |
| UniProt Entry Name: | CP4AB_HUMAN |
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