CYP46A1 Rabbit Polyclonal Antibody (CAB8573)
- SKU:
- CAB8573
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- IF
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | CYP46A1 Rabbit Polyclonal Antibody |
SKU: | CAB8573 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-280 of human CYP46A1 (NP_006659.1). |
Sequence: | HRAR SRYE HIPG PPRP SFLL GHLP CFWK KDEV GGRV LQDV FLDW AKKY GPVV RVNV FHKT SVIV TSPE SVKK FLMS TKYN KDSK MYRA LQTV FGER LFGQ GLVS ECNY ERWH KQRR VIDL AFSR SSLV SLME TFNE KAEQ LVEI LEAK ADGQ TPVS MQDM LTYT AMDI LAKA AFGM ETSM LLGA QKPL SQAV KLML EGIT ASRN TLAK FLPG KRKQ LREV RESI RFLR QVGR DWVQ RRRE ALKR GEEV PADI LTQI L |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100 |
Synonyms: | CP46; CYP46; CYP46A1 |
Positive Sample: | U-87MG,U-251MG,MCF7,Mouse liver,Mouse brain,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Microsome membrane, Single-pass membrane protein. |
Calculated MW: | 57kDa |
Observed MW: | 57kDa |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
Purification Method: | Affinity purification |
Gene ID: | 10858 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |