CYP2U1 Antibody (PACO37278)
- SKU:
- PACO37278
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CYP2U1 Antibody (PACO37278)
The CYP2U1 Polyclonal Antibody (PAC037278) is a valuable tool for research involving the cytochrome P450 family member CYP2U1, an enzyme involved in the metabolism of various endogenous compounds and xenobiotics. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CYP2U1 protein, this antibody enables researchers to detect and analyze CYP2U1 expression in different cell types, making it ideal for studies in drug metabolism, toxicology, and personalized medicine.
CYP2U1 plays a crucial role in the oxidation of fatty acids and steroids, making it a key player in lipid metabolism and hormone production. Its involvement in the metabolism of drugs and environmental chemicals also highlights its importance in understanding drug efficacy and toxicity. By studying the activity of CYP2U1, researchers can gain insights into its role in health and disease, paving the way for the development of novel therapeutic strategies targeting this enzyme.
| Antibody Name: | CYP2U1 Antibody (PACO37278) |
| Antibody SKU: | PACO37278 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Cytochrome P450 2U1 protein (363-496AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of Hela cells using PACO37278 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid, and other long chain fatty acid,. May modulate the arachidonic acid, signaling pathway and play a role in other fatty acid, signaling processes. |
| Synonyms: | Cytochrome P450 2U1 (EC 1.14.14.1), CYP2U1 |
| UniProt Protein Function: | CYP2U1: Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Oxidoreductase; Membrane protein, integral; EC 1.14.14.1; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 4q25 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm; integral to membrane Molecular Function:iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity; oxygen binding Biological Process: organic acid metabolic process; xenobiotic metabolic process; exogenous drug catabolic process; arachidonic acid metabolic process Disease: Spastic Paraplegia 56, Autosomal Recessive |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q7Z449 |
| NCBI GenInfo Identifier: | 74762432 |
| NCBI Gene ID: | 113612 |
| NCBI Accession: | Q7Z449.1 |
| UniProt Secondary Accession: | Q7Z449,Q96EQ6, B2RMV7, |
| UniProt Related Accession: | Q7Z449 |
| Molecular Weight: | 18,578 Da |
| NCBI Full Name: | Cytochrome P450 2U1 |
| NCBI Synonym Full Names: | cytochrome P450, family 2, subfamily U, polypeptide 1 |
| NCBI Official Symbol: | CYP2U1Â Â |
| NCBI Official Synonym Symbols: | SPG49; SPG56; P450TECÂ Â |
| NCBI Protein Information: | cytochrome P450 2U1; spastic paraplegia 49 |
| UniProt Protein Name: | Cytochrome P450 2U1 |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP2U1Â Â |
| UniProt Entry Name: | CP2U1_HUMAN |
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