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CYP2C8/CYP2C9/CYP2C18/CYP2C19 Antibody (PACO02540)

SKU:
PACO02540
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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CYP2C8/CYP2C9/CYP2C18/CYP2C19 Antibody (PACO02540)

The CYP2C8/CYP2C9/CYP2C18/CYP2C19 Antibody (PACO02540) is a highly specific polyclonal antibody that targets the Cytochrome P450 (CYP) enzymes CYP2C8, CYP2C9, CYP2C18, and CYP2C19. These enzymes play a crucial role in drug metabolism, specifically in the oxidation of drugs and xenobiotics in the liver.This antibody, produced in rabbits, is validated for use in applications such as Western blotting and immunohistochemistry with human samples. It binds specifically to the target enzymes, allowing for their detection and analysis in various cell types and tissues. This makes it an essential tool for research in pharmacology, toxicology, and drug development.

The CYP2C family of enzymes is known to metabolize a wide range of clinically important drugs, including anticoagulants, anticonvulsants, and nonsteroidal anti-inflammatory drugs. Understanding the activity and expression of these enzymes is crucial for predicting drug interactions, individualizing drug therapy, and minimizing adverse drug reactions.Overall, the CYP2C8/CYP2C9/CYP2C18/CYP2C19 Antibody (PACO02540) is a valuable tool for researchers studying drug metabolism, personalized medicine, and drug-drug interactions. Its high specificity and reactivity make it an excellent choice for studies aiming

Antibody Name:CYP2C8/CYP2C9/CYP2C18/CYP2C19 Antibody
Antibody SKU:PACO02540
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the Internal region of human CYP2C8/9/18/19.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:CYP2C8; Cytochrome P450 2C8; CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase; CYP2C9; CYP2C10; Cytochrome P450 2C9; (R)-limonene 6-monooxygenase; (S)-limonene
UniProt Protein Function:CYP2C8: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol). Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Lipid Metabolism - arachidonic acid; EC 1.14.14.1; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - linoleic acid; Xenobiotic Metabolism - metabolism by cytochrome P450; Cofactor and Vitamin Metabolism - retinol

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: endoplasmic reticulum membrane

Molecular Function:arachidonic acid epoxygenase activity; monooxygenase activity; oxygen binding; steroid hydroxylase activity

Biological Process: drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; organic acid metabolic process; xenobiotic metabolic process

NCBI Summary:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Code:P10632
NCBI GenInfo Identifier:117225
NCBI Gene ID:1558
NCBI Accession:P10632.2
UniProt Secondary Accession:P10632,Q5VX93, Q8WWB1, Q9UCZ9, A8K9N8, B0AZN2, B7Z1F6
UniProt Related Accession:P10632
Molecular Weight:44,358 Da
NCBI Full Name:Cytochrome P450 2C8
NCBI Synonym Full Names:cytochrome P450 family 2 subfamily C member 8
NCBI Official Symbol:CYP2C8  
NCBI Official Synonym Symbols:CPC8; CYPIIC8; MP-12/MP-20  
NCBI Protein Information:cytochrome P450 2C8
UniProt Protein Name:Cytochrome P450 2C8
UniProt Synonym Protein Names:CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase
Protein Family:Cytochrome
UniProt Gene Name:CYP2C8  
UniProt Entry Name:CP2C8_HUMAN

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