CYP2C8 Antibody (PACO23326)
- SKU:
- PACO23326
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CYP2C8 Antibody (PACO23326)
The CYP2C8 Polyclonal Antibody (PAC02326) is a valuable tool for researchers studying the cytochrome P450 2C8 enzyme, which is involved in the metabolism of various endogenous and exogenous compounds. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.The CYP2C8 enzyme is known for its role in the metabolism of drugs, environmental chemicals, and endogenous substances, making it a key player in drug metabolism and toxicology studies. By detecting and analyzing CYP2C8 protein levels in different cell types, this antibody is essential for investigating the enzyme's function in various physiological and pathological processes.
Understanding the activity of CYP2C8 is crucial for predicting drug interactions, optimizing drug dosages, and developing personalized medicine approaches. By using the CYP2C8 Polyclonal Antibody, researchers can advance their studies in pharmacology, toxicology, and drug discovery to improve patient outcomes and treatment strategies.
| Antibody Name: | CYP2C8 Antibody (PACO23326) |
| Antibody SKU: | PACO23326 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human Cytochrome P450 2C8. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HuvEc cells, using Cytochrome P450 2C8 antiobdy. |
 | Immunohistochemistry analysis of paraffin-embedded human testis tissue, using Cytochrome P450 2C8 antibody. |
| Background: | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol). |
| Synonyms: | Cytochrome P450 2C8; EC 1.14.14.1; CYPIIC8; P450 form 1; P450 MP-12/MP-20 |
| UniProt Protein Function: | CYP2C8: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol). Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - arachidonic acid; EC 1.14.14.1; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - linoleic acid; Xenobiotic Metabolism - metabolism by cytochrome P450; Cofactor and Vitamin Metabolism - retinol Chromosomal Location of Human Ortholog: 10q23.33 Cellular Component: endoplasmic reticulum membrane Molecular Function:arachidonic acid epoxygenase activity; monooxygenase activity; oxygen binding; steroid hydroxylase activity Biological Process: drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; organic acid metabolic process; xenobiotic metabolic process |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
| UniProt Code: | P10632 |
| NCBI GenInfo Identifier: | 117225 |
| NCBI Gene ID: | 1558 |
| NCBI Accession: | P10632.2 |
| UniProt Secondary Accession: | P10632,Q5VX93, Q8WWB1, Q9UCZ9, A8K9N8, B0AZN2, B7Z1F6 |
| UniProt Related Accession: | P10632 |
| Molecular Weight: | 44,358 Da |
| NCBI Full Name: | Cytochrome P450 2C8 |
| NCBI Synonym Full Names: | cytochrome P450 family 2 subfamily C member 8 |
| NCBI Official Symbol: | CYP2C8Â Â |
| NCBI Official Synonym Symbols: | CPC8; CYPIIC8; MP-12/MP-20Â Â |
| NCBI Protein Information: | cytochrome P450 2C8 |
| UniProt Protein Name: | Cytochrome P450 2C8 |
| UniProt Synonym Protein Names: | CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP2C8Â Â |
| UniProt Entry Name: | CP2C8_HUMAN |
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