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CYP2C8 Antibody (PACO02537)

SKU:
PACO02537
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323
Frequently bought together:

Description

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CYP2C8 Antibody (PACO02537)

The CYP2C8 Polyclonal Antibody (PACO02537) is a vital tool for researchers studying the CYP2C8 enzyme, which plays a crucial role in drug metabolism and bioactivation in the liver. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the CYP2C8 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component of studies in pharmacology and drug development.

CYP2C8 is a key member of the cytochrome P450 enzyme family, responsible for metabolizing a wide range of drugs, toxins, and endogenous compounds. Its involvement in drug metabolism pathways makes it a significant target for research into drug-drug interactions, personalized medicine, and drug toxicity. Understanding the function and regulation of CYP2C8 is essential for developing safe and effective therapeutic interventions that rely on accurate drug metabolism and bioactivation processes.

Antibody Name:CYP2C8 Antibody
Antibody SKU:PACO02537
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the Internal region of human CYP2C8.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:CYP2C8; Cytochrome P450 2C8; CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase
UniProt Protein Function:CYP2C8: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol). Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Lipid Metabolism - arachidonic acid; EC 1.14.14.1; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - linoleic acid; Xenobiotic Metabolism - metabolism by cytochrome P450; Cofactor and Vitamin Metabolism - retinol

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: endoplasmic reticulum membrane

Molecular Function:arachidonic acid epoxygenase activity; monooxygenase activity; oxygen binding; steroid hydroxylase activity

Biological Process: drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; organic acid metabolic process; xenobiotic metabolic process

NCBI Summary:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Code:P10632
NCBI GenInfo Identifier:117225
NCBI Gene ID:1558
NCBI Accession:P10632.2
UniProt Secondary Accession:P10632,Q5VX93, Q8WWB1, Q9UCZ9, A8K9N8, B0AZN2, B7Z1F6
UniProt Related Accession:P10632
Molecular Weight:44,358 Da
NCBI Full Name:Cytochrome P450 2C8
NCBI Synonym Full Names:cytochrome P450 family 2 subfamily C member 8
NCBI Official Symbol:CYP2C8  
NCBI Official Synonym Symbols:CPC8; CYPIIC8; MP-12/MP-20  
NCBI Protein Information:cytochrome P450 2C8
UniProt Protein Name:Cytochrome P450 2C8
UniProt Synonym Protein Names:CYPIIC8; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; Cytochrome P450 form 1; S-mephenytoin 4-hydroxylase
Protein Family:Cytochrome
UniProt Gene Name:CYP2C8  
UniProt Entry Name:CP2C8_HUMAN

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