CYP2C19 Antibody (PACO55450)
- SKU:
- PACO55450
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CYP2C19 Antibody (PACO55450)
The CYP2C19 Monoclonal Antibody (PAC055450) is a valuable tool for researchers studying the cytochrome P450 2C19 enzyme, which plays a crucial role in drug metabolism. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting CYP2C19 in human samples, making it ideal for use in Western blotting, immunohistochemistry, and ELISA assays.With its ability to bind specifically to CYP2C19, this antibody enables researchers to analyze the expression and function of this enzyme in various cell types and tissues. This is particularly important in pharmacogenomics research, as variations in CYP2C19 activity can impact drug efficacy and toxicity in patients.
By studying the role of CYP2C19 in drug metabolism, researchers can better understand individual responses to medications and tailor treatment plans for improved patient outcomes. Overall, the CYP2C19 Monoclonal Antibody (PAC055450) is a valuable tool for investigating the biological functions of the CYP2C19 enzyme and its implications for personalized medicine and drug development. Its high specificity and sensitivity make it a reliable option for researchers working in the fields of pharmacology, toxicology, and personalized medicine.
| Antibody Name: | CYP2C19 Antibody (PACO55450) |
| Antibody SKU: | PACO55450 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:300-1:500, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Cytochrome P450 2C19 protein (245-353AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse kidney tissue. All lanes: CYP2C19 antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 56 kDa. Observed band size: 56 kDa. |
 | IHC image of PACO55450 diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO55450 diluted at 1:400 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. |
| Synonyms: | Cytochrome P450 2C19 (EC 1.14.13) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Mephenytoin 4-hydroxylase), CYP2C19 |
| UniProt Protein Function: | CYP2C19: Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Belongs to the cytochrome P450 family. |
| UniProt Protein Details: | Protein type:EC 1.14.13.49; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - linoleic acid; Oxidoreductase; Lipid Metabolism - arachidonic acid; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.14.13.80; Secondary Metabolites Metabolism - limonene and pinene degradation; EC 1.14.13.48; Cofactor and Vitamin Metabolism - retinol Chromosomal Location of Human Ortholog: 10q24 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle Molecular Function:arachidonic acid epoxygenase activity; enzyme binding; heme binding; monooxygenase activity; oxidoreductase activity; oxygen binding; steroid hydroxylase activity Biological Process: drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; heterocycle metabolic process; monoterpenoid metabolic process; steroid metabolic process; xenobiotic metabolic process Disease: Drug Metabolism, Poor, Cyp2c19-related |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P33261 |
| NCBI GenInfo Identifier: | 60416369 |
| NCBI Gene ID: | 1557 |
| NCBI Accession: | P33261.3 |
| UniProt Secondary Accession: | P33261,P33259, Q8WZB1, Q8WZB2, Q9UCD4, |
| UniProt Related Accession: | P33261 |
| Molecular Weight: | 55,931 Da |
| NCBI Full Name: | Cytochrome P450 2C19 |
| NCBI Synonym Full Names: | cytochrome P450 family 2 subfamily C member 19 |
| NCBI Official Symbol: | CYP2C19Â Â |
| NCBI Official Synonym Symbols: | CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19Â Â |
| NCBI Protein Information: | cytochrome P450 2C19 |
| UniProt Protein Name: | Cytochrome P450 2C19 |
| UniProt Synonym Protein Names: | (R)-limonene 6-monooxygenase (EC:1.14.13.80); (S)-limonene 6-monooxygenase (EC:1.14.13.48); (S)-limonene 7-monooxygenase (EC:1.14.13.49); CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP2C19Â Â |
| UniProt Entry Name: | CP2CJ_HUMAN |
| Antibodies | ELISA Kits |
| CYP2C19 Antibody (PACO06400) | Human CYP2C19 / Cytochrome P450 2C19 ELISA Kit |
| Human Cytochrome P450 2C19 (CYP2C19) ELISA Kit | |
| Cytochrome P450 2C19 Colorimetric Cell-Based ELISA |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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