CYP2C19 Antibody (PACO06400)
- SKU:
- PACO06400
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CYP2C19 Antibody (PACO06400)
The CYP2C19 Antibody is a polyclonal antibody designed for research involving the CYP2C19 enzyme, which is responsible for metabolizing a wide range of drugs in the body. This antibody, raised in rabbits, is highly specific for human samples and is validated for use in various applications including Western blot and immunohistochemistry.The CYP2C19 enzyme is known for its role in drug metabolism, particularly in the activation or inactivation of certain medications. Variations in the CYP2C19 gene can lead to differences in drug response and effectiveness, making it a key target for personalized medicine and pharmacogenomic studies.
Research into the CYP2C19 enzyme is crucial for understanding the mechanisms behind drug metabolism and response variability in patients. By studying the activity and expression of CYP2C19, researchers can improve drug dosing strategies, reduce the risk of adverse drug reactions, and optimize therapeutic outcomes for individuals with different genetic profiles.
| Antibody Name: | CYP2C19 Antibody (PACO06400) |
| Antibody SKU: | PACO06400 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:5000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from the Internal region of human CYP2C19. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of HELA 293T cells using CYP2C19 Polyclonal Antibody. |
 | Western Blot analysis of MOUSE-BRAIN cells using CYP2C19 Polyclonal Antibody. |
| Synonyms: | CYP2C19; Cytochrome P450 2C19; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase |
| UniProt Protein Function: | CYP2C19: Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Belongs to the cytochrome P450 family. |
| UniProt Protein Details: | Protein type:EC 1.14.13.49; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - linoleic acid; Oxidoreductase; Lipid Metabolism - arachidonic acid; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.14.13.80; Secondary Metabolites Metabolism - limonene and pinene degradation; EC 1.14.13.48; Cofactor and Vitamin Metabolism - retinol Chromosomal Location of Human Ortholog: 10q24 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle Molecular Function:arachidonic acid epoxygenase activity; enzyme binding; heme binding; monooxygenase activity; oxidoreductase activity; oxygen binding; steroid hydroxylase activity Biological Process: drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; heterocycle metabolic process; monoterpenoid metabolic process; steroid metabolic process; xenobiotic metabolic process Disease: Drug Metabolism, Poor, Cyp2c19-related |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P33261 |
| NCBI GenInfo Identifier: | 60416369 |
| NCBI Gene ID: | 1557 |
| NCBI Accession: | P33261.3 |
| UniProt Secondary Accession: | P33261,P33259, Q8WZB1, Q8WZB2, Q9UCD4, |
| UniProt Related Accession: | P33261 |
| Molecular Weight: | 55,931 Da |
| NCBI Full Name: | Cytochrome P450 2C19 |
| NCBI Synonym Full Names: | cytochrome P450 family 2 subfamily C member 19 |
| NCBI Official Symbol: | CYP2C19Â Â |
| NCBI Official Synonym Symbols: | CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19Â Â |
| NCBI Protein Information: | cytochrome P450 2C19 |
| UniProt Protein Name: | Cytochrome P450 2C19 |
| UniProt Synonym Protein Names: | (R)-limonene 6-monooxygenase (EC:1.14.13.80); (S)-limonene 6-monooxygenase (EC:1.14.13.48); (S)-limonene 7-monooxygenase (EC:1.14.13.49); CYPIIC17; CYPIIC19; Cytochrome P450-11A; Cytochrome P450-254C; Mephenytoin 4-hydroxylase |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP2C19Â Â |
| UniProt Entry Name: | CP2CJ_HUMAN |
| ELISA Kits |
| Human CYP2C19 / Cytochrome P450 2C19 ELISA Kit |
| Human Cytochrome P450 2C19 (CYP2C19) ELISA Kit |
| Cytochrome P450 2C19 Colorimetric Cell-Based ELISA |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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