The CYP2C18 Polyclonal Antibody (CAB7431) is a valuable tool for researchers studying the CYP2C18 enzyme, which plays a crucial role in drug metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the CYP2C18 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for investigations in pharmacology and toxicology.
CYP2C18 is a member of the cytochrome P450 enzyme family and is primarily responsible for metabolizing a variety of drugs and foreign compounds in the body. Understanding the function and regulation of CYP2C18 is essential for predicting drug interactions and individualizing drug therapies. Research utilizing this antibody may lead to advancements in personalized medicine and the development of safer and more effective pharmaceuticals.
Product Name:
CYP2C18 Rabbit Polyclonal Antibody
SKU:
CAB7431
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 231-490 of human CYP2C18 (NP_000763.1).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1562
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CYP2C18 antibody (CAB7431) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
