CYP2C18/CYP2C8/CYP2C9/CYP2C19 Antibody (PACO22047)
- SKU:
- PACO22047
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CYP2C18/CYP2C8/CYP2C9/CYP2C19 Antibody (PACO22047)
The CYP2C18/CYP2C8/CYP2C9/CYP2C19 Polyclonal Antibody (PACO22047) is a specialized tool for researchers studying cytochrome P450 enzymes involved in drug metabolism and detoxification processes. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in Western blot applications. It targets the CYP2C18, CYP2C8, CYP2C9, and CYP2C19 proteins, enabling precise detection and analysis in a variety of cell types.These cytochrome P450 enzymes are essential for the metabolism of a wide range of drugs, toxins, and endogenous compounds in the body.
Variations in their activity can impact drug efficacy and toxicity, making them important factors to consider in personalized medicine and pharmacogenomics research. The CYP2C18/CYP2C8/CYP2C9/CYP2C19 Polyclonal Antibody provides researchers with a valuable tool for investigating the expression and function of these critical enzymes in health and disease.
| Antibody Name: | CYP2C18/CYP2C8/CYP2C9/CYP2C19 Antibody (PACO22047) |
| Antibody SKU: | PACO22047 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human Cytochrome P450 2C8/9/18/19. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from LOVO cells, using Cytochrome P450 2C8/9/18/19 antibody. |
| Background: | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. |
| Synonyms: | CP2CI; CPCI; CYPIIC18; EC 1.14.14.1; P450-6B/29C |
| UniProt Protein Function: | CYP2C18: a member of the cytochrome P450 superfamily of enzymes. Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. Participates in the oxidation of a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. |
| UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.14.14.1; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid Chromosomal Location of Human Ortholog: 10q24 Cellular Component: endoplasmic reticulum membrane Molecular Function:arachidonic acid epoxygenase activity; monooxygenase activity; oxygen binding; steroid hydroxylase activity Biological Process: epoxygenase P450 pathway; xenobiotic metabolic process |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P33260 |
| NCBI GenInfo Identifier: | 67476954 |
| NCBI Gene ID: | 1562 |
| NCBI Accession: | P33260.3 |
| UniProt Secondary Accession: | P33260,Q16703, Q16751, Q4VAT5, Q6GRG1, B2R8K2, |
| UniProt Related Accession: | P33260 |
| Molecular Weight: | 48,805 Da |
| NCBI Full Name: | Cytochrome P450 2C18 |
| NCBI Synonym Full Names: | cytochrome P450 family 2 subfamily C member 18 |
| NCBI Official Symbol: | CYP2C18Â Â |
| NCBI Official Synonym Symbols: | CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29CÂ Â |
| NCBI Protein Information: | cytochrome P450 2C18 |
| UniProt Protein Name: | Cytochrome P450 2C18 |
| UniProt Synonym Protein Names: | CYPIIC18; Cytochrome P450-6b/29c |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP2C18Â Â |
| UniProt Entry Name: | CP2CI_HUMAN |
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