CYP2A7 Antibody (PACO22785)
- SKU:
- PACO22785
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
CYP2A7 Antibody (PACO22785)
The CYP2A7 Monoclonal Antibody (PACO22785) is a valuable tool for research involving the cytochrome P450 protein family, specifically CYP2A7. This antibody, produced using hybridoma technology, offers high specificity and sensitivity for detecting CYP2A7 in human samples. It has been validated for use in various applications, including Western blot and immunohistochemistry.CYP2A7 is a member of the cytochrome P450 enzyme family, which plays a crucial role in drug metabolism and detoxification processes in the liver.
Studies have shown that CYP2A7 expression is altered in certain diseases, such as cancer and liver disorders, making it a potential biomarker for these conditions. By utilizing the CYP2A7 Monoclonal Antibody, researchers can gain insights into the role of this enzyme in health and disease, paving the way for new therapeutic strategies and drug development.
| Antibody Name: | CYP2A7 Antibody (PACO22785) |
| Antibody SKU: | PACO22785 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from Internal of human CYP2A7. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from K562/Jurkat cells, using CYP2A7 antibody. |
| Background: | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. |
| Synonyms: | CP2A7; CPA7; CPAD; CYP2A; CYP2A7 |
| UniProt Protein Function: | CYP2A7: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family.Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 1.14.14.1; Endoplasmic reticulum; Secondary Metabolites Metabolism - caffeineChromosomal Location of Human Ortholog: 19q13.2Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasmMolecular Function: iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen bindingBiological Process: coumarin metabolic process; xenobiotic metabolic process; exogenous drug catabolic process; epoxygenase P450 pathway |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P20853 |
| NCBI GenInfo Identifier: | 15147330 |
| NCBI Gene ID: | 1549 |
| NCBI Accession: | NP_000755.2 |
| UniProt Secondary Accession: | P20853,Q13121 |
| UniProt Related Accession: | P20853 |
| Molecular Weight: | 56,425 Da |
| NCBI Full Name: | cytochrome P450 2A7 isoform 1 |
| NCBI Synonym Full Names: | cytochrome P450, family 2, subfamily A, polypeptide 7 |
| NCBI Official Symbol: | CYP2A7Â Â |
| NCBI Official Synonym Symbols: | CPA7; CPAD; CYP2A; CYPIIA7; P450-IIA4Â Â |
| NCBI Protein Information: | cytochrome P450 2A7; cytochrome P450IIA4; cytochrome P450 IIA4; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7 |
| UniProt Protein Name: | Cytochrome P450 2A7 |
| UniProt Synonym Protein Names: | CYPIIA7; Cytochrome P450 IIA4 |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYP2A7Â Â |
| UniProt Entry Name: | CP2A7_HUMAN |
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