The CYP2A7 Polyclonal Antibody (PACO03553) is a valuable tool for researchers studying the CYP2A7 enzyme, which belongs to the cytochrome P450 family and is involved in drug metabolism and detoxification processes in the liver. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications.CYP2A7 plays a crucial role in the metabolism of various compounds, including drugs, carcinogens, and environmental toxins. Its expression levels and activity can impact an individual's response to certain medications and their susceptibility to toxic substances. By targeting CYP2A7 with this antibody, researchers can effectively detect and analyze the enzyme in different experimental settings, providing insights into its function and potential implications in drug metabolism and toxicity studies.
The versatility and reliability of the CYP2A7 Polyclonal Antibody make it an essential resource for scientists investigating the role of cytochrome P450 enzymes in drug metabolism, chemical detoxification, and other biological processes. With its ability to specifically recognize CYP2A7 in human samples, this antibody is invaluable for advancing research in pharmacology, toxicology, and personalized medicine.
Antibody Name:
CYP2A7 Antibody
Antibody SKU:
PACO03553
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human CYP2A6/7.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
CYP2A7: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family.Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 1.14.14.1; Endoplasmic reticulum; Secondary Metabolites Metabolism - caffeineChromosomal Location of Human Ortholog: 19q13.2Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasmMolecular Function: iron ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen bindingBiological Process: coumarin metabolic process; xenobiotic metabolic process; exogenous drug catabolic process; epoxygenase P450 pathway
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
