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CYP2A6/CYP2A7/CYP2A13 Antibody (PACO01811)

SKU:
PACO01811
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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CYP2A6/CYP2A7/CYP2A13 Antibody (PACO01811)

The CYP2A6/CYP2A7/CYP2A13 Polyclonal Antibody (PACO01811) is a valuable tool for researchers studying the cytochrome P450 enzymes CYP2A6, CYP2A7, and CYP2A13. These enzymes play crucial roles in the metabolism of various endogenous and exogenous compounds, including drugs, toxins, and carcinogens. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. It binds specifically to the CYP2A6, CYP2A7, and CYP2A13 proteins, enabling accurate detection and quantification in a variety of cell types and tissues.The CYP2A family of enzymes is involved in the biotransformation of a wide range of compounds, making them important targets for research in pharmacology, toxicology, and cancer biology.

By understanding the functions and regulation of these enzymes, researchers can gain valuable insights into drug metabolism, toxicity, and the development of new therapeutic agents. Overall, the CYP2A6/CYP2A7/CYP2A13 Polyclonal Antibody is an essential tool for investigating the roles of these key enzymes in health and disease, offering valuable insights that have the potential to advance our understanding of drug metabolism and personalized medicine.

Antibody Name:CYP2A6/CYP2A7/CYP2A13 Antibody
Antibody SKU:PACO01811
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the Internal region of human CYP2A6/7/13.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:CYP2A6; CYP2A3; Cytochrome P450 2A6; 1,4-cineole 2-exo-monooxygenase; CYPIIA6; Coumarin 7-hydroxylase; Cytochrome P450 IIA3; Cytochrome P450(I); CYP2A7; Cytochrome P450 2A7; CYPIIA7; Cytochrome P450 IIA4; CYP2A13; Cytochrome P450 2A13; CYPIIA13
UniProt Protein Function:CYP2A6: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4- cineole 2-exo-monooxygenase. Possesses low phenacetin O- deethylation activity. Belongs to the cytochrome P450 family.
UniProt Protein Details:

Protein type:Endoplasmic reticulum; EC 1.14.14.1; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase; Secondary Metabolites Metabolism - caffeine

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasmic microtubule

Molecular Function:coumarin 7-hydroxylase activity; enzyme binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen binding

Biological Process: steroid metabolic process; coumarin metabolic process; xenobiotic metabolic process; coumarin catabolic process; exogenous drug catabolic process; epoxygenase P450 pathway; drug metabolic process

Disease: Tobacco Addiction, Susceptibility To; Lung Cancer; Coumarin Resistance

NCBI Summary:This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008]
UniProt Code:P11509
NCBI GenInfo Identifier:308153612
NCBI Gene ID:1548
NCBI Accession:P11509.3
UniProt Secondary Accession:P11509,P00190, P10890, Q16803, Q4VAT9, Q4VAU0, Q4VAU1 Q9H1Z7, Q9UCU0, Q9UK48, A7YAE5, B2R7F6,
UniProt Related Accession:P11509
Molecular Weight:494
NCBI Full Name:Cytochrome P450 2A6
NCBI Synonym Full Names:cytochrome P450, family 2, subfamily A, polypeptide 6
NCBI Official Symbol:CYP2A6  
NCBI Official Synonym Symbols:CPA6; CYP2A; CYP2A3; P450PB; CYPIIA6; P450C2A  
NCBI Protein Information:cytochrome P450 2A6; cytochrome P450(I); cytochrome P450 IIA3; coumarin 7-hydroxylase; xenobiotic monooxygenase; 1,4-cineole 2-exo-monooxygenase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 6
UniProt Protein Name:Cytochrome P450 2A6
UniProt Synonym Protein Names:1,4-cineole 2-exo-monooxygenase; CYPIIA6; Coumarin 7-hydroxylase; Cytochrome P450 IIA3; Cytochrome P450(I)
Protein Family:Cytochrome
UniProt Gene Name:CYP2A6  
UniProt Entry Name:CP2A6_HUMAN

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