The CYP2A13 Polyclonal Antibody (PACO00663) is a valuable tool for researchers studying cytochrome P450 2A13, an enzyme involved in the metabolism of various chemicals and drugs in the body. This antibody is produced in rabbits and exhibits high specificity and reactivity with human samples, making it ideal for use in Western blot applications.Cytochrome P450 2A13 plays a crucial role in the detoxification and activation of a wide range of compounds, including carcinogens found in tobacco smoke. By targeting this enzyme, researchers can gain insights into the mechanisms behind drug metabolism, chemical detoxification, and potential drug interactions.
The CYP2A13 Polyclonal Antibody enables the detection and analysis of cytochrome P450 2A13 in different cell types, making it a valuable tool for studies in pharmacology, toxicology, and cancer research.Understanding the expression and activity of cytochrome P450 2A13 is essential for developing personalized medicine strategies, assessing drug efficacy, and evaluating the effects of environmental toxins on human health. By utilizing the CYP2A13 Polyclonal Antibody in their research, scientists can uncover new insights into the role of this enzyme in health and disease.
Antibody Name:
CYP2A13 Antibody
Antibody SKU:
PACO00663
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human CYP2A13.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CYP2A13; Cytochrome P450 2A13; CYPIIA13
UniProt Protein Function:
CYP2A5: Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N- dimethylaniline, 2'-methoxyacetophenone, N- nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. Belongs to the cytochrome P450 family.Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.14.14.1; Oxidoreductase; Cofactor and Vitamin Metabolism - retinol; Secondary Metabolites Metabolism - caffeineChromosomal Location of Human Ortholog: 19q13.2Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasmMolecular Function: iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen bindingBiological Process: coumarin metabolic process; xenobiotic metabolic process; exogenous drug catabolic process; epoxygenase P450 pathway
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
