CYP27B1 Rabbit Polyclonal Antibody (CAB1716)
- SKU:
- CAB1716
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | CYP27B1 Rabbit Polyclonal Antibody |
SKU: | CAB1716 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-195 of human CYP27B1 (NP_000776.1). |
Sequence: | LGYR EYHS ARRS LADI PGPS TPSF LAEL FCKG GLSR LHEL QVQG AAHF GPVW LASF GTVR TVYV AAPA LVEE LLRQ EGPR PERC SFSP WTEH RRCR QRAC GLLT AEGE EWQR LRSL LAPL LLRP QAAA RYAG TLNN VVCD LVRR LRRQ RGRG TGPP ALVR DVAG EFYK FGL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | VDR; CP2B; CYP1; PDDR; VDD1; VDDR; VDDRI; CYP27B; P450c1; CYP1alpha; CYP27B1 |
Positive Sample: | Rat kidney,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion membrane. |
Calculated MW: | 57kDa |
Observed MW: | 63kDa |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
Purification Method: | Affinity purification |
Gene ID: | 1594 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |