The CYP26C1 Polyclonal Antibody (PACO59149) is a valuable tool for researchers studying the CYP26C1 protein, a key enzyme involved in the metabolism of retinoic acid. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.CYP26C1 is known for its role in the regulation of retinoic acid levels, which play a critical role in processes such as embryonic development, cell differentiation, and immune function.
Dysregulation of CYP26C1 expression has been linked to various disorders, including cancer and developmental defects.By targeting the CYP26C1 protein, this antibody enables researchers to detect and analyze the enzyme in different cell types, making it an essential tool in studies related to metabolism, development, and disease. Understanding the function of CYP26C1 can aid in the development of therapies for conditions associated with retinoic acid imbalance.
Antibody Name:
CYP26C1 Antibody (PACO59149)
Antibody SKU:
PACO59149
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Cytochrome P450 26C1 protein (331-460AA)
Immunofluorescence staining of HepG2 cells with PACO59149 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Plays a role in retinoic acid, metabolism. Acts on retinoids, including all-trans-retinoic acid, (RA) and its stereoisomer 9-cis-RA (preferred substrate).
Synonyms:
Cytochrome P450 26C1 (EC 1.14), CYP26C1
UniProt Protein Function:
CYP26C1: Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate). Belongs to the cytochrome P450 family.Protein type: Membrane protein, integral; Cell development/differentiation; Cofactor and Vitamin Metabolism - retinol; Oxidoreductase; EC 1.14.-.-Chromosomal Location of Human Ortholog: 10q23.33Cellular Component: endoplasmic reticulum membraneMolecular Function: retinoic acid 4-hydroxylase activity; retinoic acid bindingBiological Process: anterior/posterior pattern formation; central nervous system development; neural crest cell development; organelle fusion; vitamin metabolic processDisease: Focal Facial Dermal Dysplasia 4
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008]
