The CYP26C1 Polyclonal Antibody (PAC004102) is a valuable tool for researchers studying the cytochrome P450 family member CYP26C1, an enzyme involved in the metabolism of retinoic acid, a form of vitamin A. This rabbit-raised antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the CYP26C1 protein, this antibody allows for the detection and analysis of CYP26C1 in various cell types, making it ideal for research in fields such as drug metabolism, developmental biology, and cancer research.
CYP26C1 plays a critical role in regulating the levels of retinoic acid in cells, making it a key player in processes such as cell differentiation, growth, and apoptosis. Dysregulation of CYP26C1 activity has been implicated in various diseases, making it a potential therapeutic target for conditions such as cancer, developmental disorders, and vitamin A deficiency. Understanding the function of CYP26C1 is essential for developing targeted treatments that modulate retinoic acid metabolism in a precise and effective manner.
Antibody Name:
CYP26C1 Antibody
Antibody SKU:
PACO04102
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the N-terminal region of human CYP26C1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CYP26C1; Cytochrome P450 26C1
UniProt Protein Function:
CYP26C1: Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate). Belongs to the cytochrome P450 family.Protein type: Membrane protein, integral; Cell development/differentiation; Cofactor and Vitamin Metabolism - retinol; Oxidoreductase; EC 1.14.-.-Chromosomal Location of Human Ortholog: 10q23.33Cellular Component: endoplasmic reticulum membraneMolecular Function: retinoic acid 4-hydroxylase activity; retinoic acid bindingBiological Process: anterior/posterior pattern formation; central nervous system development; neural crest cell development; organelle fusion; vitamin metabolic processDisease: Focal Facial Dermal Dysplasia 4
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008]
