The CYP26C1 Polyclonal Antibody (PACO04101) is a valuable tool for researchers studying the Cytochrome P450 family member CYP26C1, an enzyme involved in the metabolism of retinoic acid. This antibody, produced in house as a polyclonal antibody in rabbits, exhibits high specificity and sensitivity towards CYP26C1 in human samples.CYP26C1 plays a crucial role in the regulation of retinoic acid levels, which is important for various biological processes including embryonic development, cell differentiation, and immune function. Dysregulation of CYP26C1 has been implicated in various diseases, making it a potential target for drug discovery and therapeutic interventions.
Validated for use in Western blot applications, the CYP26C1 Polyclonal Antibody enables precise detection and quantification of CYP26C1 protein levels in different cell types and tissues. Its reliability and accuracy make it an essential tool for researchers in the fields of pharmacology, toxicology, and developmental biology. Discover the potential of CYP26C1 and advance your research with the PACO04101 antibody.
Antibody Name:
CYP26C1 Antibody
Antibody SKU:
PACO04101
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human CYP26C1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CYP26C1; Cytochrome P450 26C1
UniProt Protein Function:
CYP26C1: Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate). Belongs to the cytochrome P450 family.Protein type: Membrane protein, integral; Cell development/differentiation; Cofactor and Vitamin Metabolism - retinol; Oxidoreductase; EC 1.14.-.-Chromosomal Location of Human Ortholog: 10q23.33Cellular Component: endoplasmic reticulum membraneMolecular Function: retinoic acid 4-hydroxylase activity; retinoic acid bindingBiological Process: anterior/posterior pattern formation; central nervous system development; neural crest cell development; organelle fusion; vitamin metabolic processDisease: Focal Facial Dermal Dysplasia 4
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008]
