The CYP26A1 Polyclonal Antibody (CAB16259) is a vital tool for researchers studying the CYP26A1 enzyme, a key player in the regulation of retinoic acid metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been rigorously validated for Western blot applications. By targeting the CYP26A1 protein, this antibody enables precise detection and analysis in various cell types, making it an essential asset for investigations in the fields of pharmacology and developmental biology.CYP26A1, a member of the cytochrome P450 family, plays a crucial role in maintaining proper levels of retinoic acid, a signaling molecule essential for embryonic development and tissue homeostasis.
Dysregulation of CYP26A1 activity has been associated with a variety of pathological conditions, including developmental disorders and cancer. By elucidating the functions of CYP26A1, researchers can gain valuable insights into the mechanisms underlying these diseases, paving the way for the development of novel therapeutic interventions targeting this enzyme.
Product Name:
CYP26A1 Rabbit Polyclonal Antibody
SKU:
CAB16259
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CYP26A1 (NP_000774.2).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported.
Purification Method:
Affinity purification
Gene ID:
1592
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using CYP26A1 Rabbit pAb (CAB16259) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
