The CYP1B1 Polyclonal Antibody (CAB13967) is a valuable tool for researchers studying the cytochrome P450 1B1 enzyme, which plays a key role in the metabolism of numerous endogenous and exogenous compounds. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.Cytochrome P450 1B1 is involved in the metabolism of a wide range of substrates, including steroid hormones, environmental toxins, and carcinogens. Dysregulation of CYP1B1 activity has been implicated in several diseases, making it an important target for research in fields such as toxicology, pharmacology, and oncology.
By using the CYP1B1 Polyclonal Antibody, researchers can effectively detect and analyze the expression of CYP1B1 in different tissues and cell types, allowing for a better understanding of its role in metabolism and disease pathogenesis. This antibody is a valuable tool for advancing research in drug development, personalized medicine, and environmental health studies.
Product Name:
CYP1B1 Rabbit Polyclonal Antibody
SKU:
CAB13967
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 244-543 of human CYP1B1 (NP_000095.2).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.
Purification Method:
Affinity purification
Gene ID:
1545
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of HeLa cells using CYP1B1 antibody (CAB13967) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
