CYP1A1 Rabbit Polyclonal Antibody (CAB2159)
- SKU:
- CAB2159
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
Product Name: | CYP1A1 Rabbit Polyclonal Antibody |
SKU: | CAB2159 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-460 of human CYP1A1 (NP_000490.1). |
Sequence: | AICF GRRY DHNH QELL SLVN LNNN FGEV VGSG NPAD FIPI LRYL PNPS LNAF KDLN EKFY SFMQ KMVK EHYK TFEK GHIR DITD SLIE HCQE KQLD ENAN VQLS DEKI INIV LDLF GAGF DTVT TAIS WSLM YLVM NPRV QRKI QEEL DTVI GRSR RPRL SDRS HLPY MEAF ILET FRHS SFVP FTIP HSTT RDTS LKGF YIPK GRCV FVNQ WQIN HDQK LWVN PSEF LPER FLTP DGAI DKVL SEKV IIFG MGKR KCIG E |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX; CYP1A1 |
Positive Sample: | Mouse liver,Mouse stomach |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Microsome membrane, Peripheral membrane protein. |
Calculated MW: | 58kDa |
Observed MW: | 55kDa |
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method: | Affinity purification |
Gene ID: | 1543 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |