CYP17A1 Rabbit Polyclonal Antibody (CAB1373)
- SKU:
- CAB1373
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | CYP17A1 Rabbit Polyclonal Antibody |
SKU: | CAB1373 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 209-508 of human CYP17A1 (NP_000093.1). |
Sequence: | LSKD SLVD LVPW LKIF PNKT LEKL KSHV KIRN DLLN KILE NYKE KFRS DSIT NMLD TLMQ AKMN SDNG NAGP DQDS ELLS DNHI LTTI GDIF GAGV ETTT SVVK WTLA FLLH NPQV KKKL YEEI DQNV GFSR TPTI SDRN RLLL LEAT IREV LRLR PVAP MLIP HKAN VDSS IGEF AVDK GTEV IINL WALH HNEK EWHQ PDQF MPER FLNP AGTQ LISP SVSY LPFG AGPR SCIG EILA RQEL FLIM AWLL QRFD LEVP DDGQ LPSL EGIP KVVF LIDS FKVK IKVR QAWR EAQA EGST |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CPT7; CYP17; S17AH; P450C17; CYP17A1 |
Positive Sample: | Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane. |
Calculated MW: | 57kDa |
Observed MW: | 57kDa |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
Purification Method: | Affinity purification |
Gene ID: | 1586 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |