The CYP11B2 Polyclonal Antibody (CAB1443) is a valuable tool for researchers studying the CYP11B2 enzyme, which is involved in the biosynthesis of aldosterone, a hormone critical for regulating salt and water balance in the body. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications.CYP11B2, also known as aldosterone synthase, is a key enzyme in the renin-angiotensin-aldosterone system, playing a crucial role in maintaining blood pressure and electrolyte balance. Dysregulation of CYP11B2 activity has been implicated in various disorders, including hypertension and primary aldosteronism.
The CYP11B2 Polyclonal Antibody enables researchers to detect and analyze the expression of this enzyme in different cell types, facilitating investigation into its role in physiology and disease pathology.By gaining insights into the function of CYP11B2, researchers can further our understanding of conditions associated with hormonal imbalances and develop targeted therapies for diseases related to aldosterone dysregulation. The CYP11B2 Polyclonal Antibody is a valuable tool for advancing research in endocrinology, cardiovascular health, and related fields.
Product Name:
CYP11B2 Rabbit Polyclonal Antibody
SKU:
CAB1443
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 234-503 of human CYP11B2 (NP_000489.3).
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.
Purification Method:
Affinity purification
Gene ID:
1585
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CYP11B2 Rabbit pAb (CAB1443) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 20s.
