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CYP11B1/CYP11B2 Antibody (PACO00660)

SKU:
PACO00660
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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CYP11B1/CYP11B2 Antibody (PACO00660)

The CYP11B1/CYP11B2 Antibody (PACO00660) is a polyclonal antibody specifically designed for research involving the CYP11B1 and CYP11B2 proteins, which are key enzymes involved in steroid hormone biosynthesis. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in a variety of applications, including Western blotting.The CYP11B1 and CYP11B2 enzymes play a crucial role in the synthesis of mineralocorticoids and glucocorticoids, hormones essential for maintaining fluid balance, electrolyte regulation, and stress responses in the body. Dysregulation of these enzymes has been implicated in various diseases, including hypertension, hyperaldosteronism, and adrenal hyperplasia, making them important targets for research in endocrinology and related fields.

This antibody enables the detection and analysis of CYP11B1 and CYP11B2 proteins in different cell types, providing valuable insight into their roles in steroid hormone production and metabolism. Further understanding of the function and regulation of these enzymes may lead to the development of novel therapeutic interventions for disorders associated with steroid hormone imbalances.

Antibody Name:CYP11B1/CYP11B2 Antibody
Antibody SKU:PACO00660
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the C-terminal region of human CYP11B1/2.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:CYP11B1; S11BH; Cytochrome P450 11B1; mitochondrial; CYPXIB1; Cytochrome P-450c11; Cytochrome P450C11; Steroid 11-beta-hydroxylase; CYP11B2; Cytochrome P450 11B2, mitochondrial; Aldosterone synthase; ALDOS; Aldosterone-synthesizing enzyme;
UniProt Protein Function:CYP11B1: Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB. Defects in CYP11B1 are the cause of adrenal hyperplasia type 4 (AH4). AH4 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: salt wasting (SW, the most severe type), simple virilizing (SV, less severely affected patients), with normal aldosterone biosynthesis, non-classic form or late onset (NC or LOAH), and cryptic (asymptomatic). AH4 patients usually have hypertension. Defects in CYP11B1 are a cause of familial hyperaldosteronism type 1 (FH1). It is a disorder characterized by hypertension, variable hyperaldosteronism, and abnormal adrenal steroid production, including 18-oxocortisol and 18-hydroxycortisol. There is significant phenotypic heterogeneity, and some individuals never develop hypertension. The molecular defect causing hyperaldosteronism familial type 1 is an anti-Lepore-type fusion of the CYP11B1 and CYP11B2 genes. The hybrid gene has the promoting part of CYP11B1, ACTH-sensitive, and the coding part of CYP11B2. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Oxidoreductase; EC 1.14.15.4; Lipid Metabolism - C21-steroid hormone; Mitochondrial; Lipid Metabolism - androgen and estrogen

Chromosomal Location of Human Ortholog: 8q21

Cellular Component: mitochondrion; mitochondrial inner membrane

Molecular Function:steroid 11-beta-monooxygenase activity; iron ion binding; heme binding

Biological Process: steroid metabolic process; regulation of blood pressure; xenobiotic metabolic process; C21-steroid hormone biosynthetic process; immune response; glucocorticoid biosynthetic process; glucose homeostasis; sterol metabolic process; aldosterone biosynthetic process; cellular response to hormone stimulus

Disease: Glucocorticoid-remediable Aldosteronism; Adrenal Hyperplasia, Congenital, Due To Steroid 11-beta-hydroxylase Deficiency

NCBI Summary:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P15538
NCBI GenInfo Identifier:215274267
NCBI Gene ID:1584
NCBI Accession:P15538.5
UniProt Secondary Accession:P15538,Q14095, Q4VAQ8, Q4VAQ9, Q9UML2,
UniProt Related Accession:P15538
Molecular Weight:
NCBI Full Name:Cytochrome P450 11B1, mitochondrial
NCBI Synonym Full Names:cytochrome P450, family 11, subfamily B, polypeptide 1
NCBI Official Symbol:CYP11B1  
NCBI Official Synonym Symbols:FHI; CPN1; CYP11B; P450C11  
NCBI Protein Information:cytochrome P450 11B1, mitochondrial; CYPXIB1; cytochrome P450C11; cytochrome P-450c11; cytochrome p450 XIB1; steroid 11-beta-hydroxylase; steroid 11-beta-monooxygenase; cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1
UniProt Protein Name:Cytochrome P450 11B1, mitochondrial
UniProt Synonym Protein Names:CYPXIB1; Cytochrome P-450c11; Cytochrome P450C11; Steroid 11-beta-hydroxylase (EC:1.14.15.4)
Protein Family:Cytochrome
UniProt Gene Name:CYP11B1  
UniProt Entry Name:C11B1_HUMAN

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