Cyclin T1 Rabbit Polyclonal Antibody (CAB2057)
- SKU:
- CAB2057
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
Product Name: | Cyclin T1 Rabbit Polyclonal Antibody |
SKU: | CAB2057 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 220-320 of human Cyclin T1 (NP_001231.2). |
Sequence: | HWWE YVDA TVTL ELLD ELTH EFLQ ILEK TPNR LKRI WNWR ACEA AKKT KADD RGTD EKTS EQTI LNMI SQSS SDTT IAGL MSMS TSTT SAVP SLPV SEES S |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 |
Synonyms: | CCNT; CYCT1; HIVE1; Cyclin T1 |
Positive Sample: | Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 81kDa |
Observed MW: | 81kDa |
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 904 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |