The Cyclin K Polyclonal Antibody (CAB10261) is a valuable tool for researchers studying cyclin K, a protein that plays a key role in the regulation of cell cycle progression and transcriptional activation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Cyclin K is a critical component of the P-TEFb complex, which is involved in the regulation of RNA polymerase II elongation and transcriptional activation. Dysregulation of cyclin K has been implicated in various diseases, including cancer, making it a promising target for therapeutic intervention.
By targeting cyclin K with this polyclonal antibody, researchers can detect and analyze the protein in different cell types, providing valuable insights into its function and potential roles in disease pathogenesis. With its specificity and reliability, this antibody is an essential tool for studies in molecular biology, cancer research, and drug development.
Product Name:
Cyclin K Rabbit Polyclonal Antibody
SKU:
CAB10261
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human Cyclin K (NP_001092872.1).
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.
Purification Method:
Affinity purification
Gene ID:
8812
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cyclin K Rabbit pAb (CAB10261) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
