The Cyclin I Polyclonal Antibody (CAB17623) is a valuable tool for research involving Cyclin I, a protein involved in cell cycle regulation. This rabbit-derived antibody is highly specific for human samples and is validated for use in Western blot applications. By binding to Cyclin I, this antibody allows for the detection and analysis of this important protein in a variety of cell types, making it an ideal choice for studies in cell biology, cancer research, and drug development.Cyclin I plays a crucial role in the progression of the cell cycle, specifically in the G1 phase where it helps regulate the transition from G0 to G1.
Dysregulation of Cyclin I has been implicated in various diseases, including cancer, making it a promising target for therapeutic interventions. By using the Cyclin I Polyclonal Antibody, researchers can gain valuable insights into the mechanisms underlying cell cycle progression and potential therapeutic strategies for treating diseases associated with cell cycle dysregulation.
Product Name:
Cyclin I Rabbit Polyclonal Antibody
SKU:
CAB17623
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 257-377 of human Cyclin I (NP_006826.1).
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression.
Purification Method:
Affinity purification
Gene ID:
10983
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cyclin I Rabbit pAb (CAB17623) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
