The Cyclin H Rabbit Monoclonal Antibody (CAB4076) is a powerful tool for researchers studying cyclin H, a key regulator of the cell cycle. This antibody, produced in rabbits, is highly specific and reacts strongly with human samples, making it an ideal choice for Western blot applications. By binding to cyclin H, this antibody allows for the accurate detection and analysis of this protein in a variety of cell types.Cyclin H is involved in the control of cell division and plays a crucial role in regulating the progression of the cell cycle. Dysregulation of cyclin H has been linked to various diseases, including cancer, making it a promising target for cancer research.
By using this antibody, researchers can gain valuable insights into the function of cyclin H and its potential role in disease development.Overall, the Cyclin H Rabbit Monoclonal Antibody (CAB4076) is a valuable tool for researchers interested in studying cell cycle regulation, cancer biology, and other related fields. Its high specificity and reactivity make it a reliable choice for immunological studies, providing accurate and reproducible results.
Product Name:
Cyclin H Rabbit Monoclonal Antibody
SKU:
CAB4076
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 224-323 of human Cyclin H (P51946).
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
902
Clone Number:
ARC0893
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cyclin H Rabbit mAb (CAB4076) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
