The Cyclin H Polyclonal Antibody is a valuable tool for researchers studying Cyclin H, a key regulator of cell cycle progression. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting Cyclin H in human samples, making it ideal for use in Western blot applications. By targeting the Cyclin H protein, this antibody allows for precise and reliable analysis of cell cycle dynamics in various cell types.Cyclin H is essential for the proper functioning of cyclin-dependent kinases, crucial enzymes involved in cell division. Dysregulation of Cyclin H has been implicated in various diseases, including cancer, making it a promising therapeutic target.
By studying the expression and activity of Cyclin H using this antibody, researchers can gain valuable insights into the mechanisms underlying cell cycle control and potentially identify novel strategies for treating cancer and other proliferative disorders.Overall, the Cyclin H Polyclonal Antibody is a valuable tool for researchers interested in unraveling the complexities of cell cycle regulation and identifying new targets for therapeutic intervention. Its high specificity and sensitivity make it a reliable choice for studying Cyclin H in a variety of experimental settings.
Product Name:
Cyclin H Polyclonal Antibody
SKU:
CAB21703
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human Cyclin H (NP_001230.1).
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
902
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cyclin H Rabbit pAb (CAB21703).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).
