Cyclin H Polyclonal Antibody (CAB21703)
- SKU:
- CAB21703
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | Cyclin H Polyclonal Antibody |
SKU: | CAB21703 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human Cyclin H (NP_001230.1). |
Sequence: | MYHN SSQK RHWT FSSE EQLA RLRA DANR KFRC KAVA NGKV LPND PVFL EPHE EMTL CKYY EKRL LEFC SVFK PAMP RSVV GTAC MYFK RFYL NNSV MEYH PRII MLTC AFLA CKVD EFNV SSPQ FVGN LRES PLGQ EKAL EQIL EYEL LLIQ QLNF HLIV HNPY RPFE GFLI DLKT RYPI LENP EILR KTAD DFLN RIAL TDAY LLYT PSQI ALTA ILSS ASRA GITM ESYL SESL MLKE NRTC LSQL LDIM KSMR NLVK KYEP PRSE EVAV LKQK LERC HSAE LALN VITK KRKG YEDD DYVS KKSK HEEE EWTD DDLV ESL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CAK; p34; p37; CycH; Cyclin H |
Positive Sample: | Jurkat,K-562,SW620,HT-29,MCF7 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 38kDa |
Observed MW: | Refer to figures |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 902 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |