The Cyclin D3 Rabbit Monoclonal Antibody (CAB3989) is a valuable tool for researchers studying Cyclin D3, a protein involved in cell cycle progression and regulation. This antibody, generated in rabbits, is highly specific to Cyclin D3 and is validated for use in various applications, including Western blot and immunohistochemistry.Cyclin D3 plays a key role in regulating cell division and proliferation, making it a crucial target for cancer research and drug development. By detecting and analyzing Cyclin D3 levels in cell samples, researchers can gain insight into the mechanisms underlying cell cycle control and potential therapeutic interventions.
Furthermore, the high reactivity of this antibody with human samples makes it an essential tool for studying Cyclin D3 expression in clinical samples, providing valuable information for understanding its role in cancer progression and potentially identifying new biomarkers for diagnosis and prognosis.Overall, the Cyclin D3 Rabbit Monoclonal Antibody (CAB3989) offers researchers a reliable and specific tool for investigating the function of Cyclin D3 in various biological processes, with potential implications for cancer research and treatment strategies.
Product Name:
Cyclin D3 Rabbit Monoclonal Antibody
SKU:
CAB3989
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 202-292 of human Cyclin D3 (P30281).
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
896
Clone Number:
ARC0325
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Cyclin D3 Rabbit mAb (CAB3989) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
