Cyclin A1 Rabbit Polyclonal Antibody (CAB5631)
- SKU:
- CAB5631
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | Cyclin A1 Rabbit Polyclonal Antibody |
SKU: | CAB5631 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human CCNA1 (NP_001104515.1). |
Sequence: | METG FPAI MYPG SFIG GWGE EYLS WEGP GLPD FVFQ QPVE SEAM HCSN PKSG VVLA TVAR GPDA CQIL TRAP LGQD PPQR TVLG LLTA NGQY RRTC GQGI TRIR CYSG SENA FPPA GKKA LPDC GVQE PPKQ GFDI YMDE LEQG DRDS CSVR EGMA FEDV YEVD TGTL KSDL HFLL DFNT VSPM LVDS SLLS QSED ISSL GTDV INVT EYAE EIYQ YLRE AEIR HRPK AH |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CT146; Cyclin A1 |
Positive Sample: | HL-60,U-87MG,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 52kDa |
Observed MW: | 52kDa |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 8900 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |