NOX2/gp91phox Rabbit Polyclonal Antibody (CAB12430)
- SKU:
- CAB12430
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | NOX2/gp91phox Rabbit Polyclonal Antibody |
SKU: | CAB12430 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 101-200 of human NOX2/gp91phox (NP_000388.2). |
Sequence: | HKMV AWMI ALHS AIHT IAHL FNVE WCVN ARVN NSDP YSVA LSEL GDRQ NESY LNFA RKRI KNPE GGLY LAVT LLAG ITGV VITL CLIL IITS STKT IRRS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CGD; CGDX; NOX2; IMD34; AMCBX2; GP91-1; GP91PHOX; p91-PHOX; GP91-PHOX; NOX2/gp91phox |
Positive Sample: | RAW 264.7 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Multi-pass membrane protein. |
Calculated MW: | 65kDa |
Observed MW: | 60kDa |
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
Purification Method: | Affinity purification |
Gene ID: | 1536 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |